Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity.
应用类型
WB
免疫原
A synthetic phosphopeptide corresponding to residues surrounding Ser310 of human Presenilin 1
