Cambinol is a cell-permeable β-naphthol compound that inhibits the NAD-dependent deacetylase activity of hSIRT1 and hSIRT2 （IC50 = 56 uM and 59 uM， respectively） in a substrate-， but not NAD-， competitive manner. It inhibits SIRT5 deacetylase activity only at much higher concentrations （IC50 >300 uM） and exhibits no inhibition against class I and II HDACs. Cambinol-induced apoptosis in BCL6-expressing Burkitt lymphoma cell lines has been attributed to the hyperacetylation of BCL6 and p53. Shown to effectively inhibit xenografted Daudi Burkitt lymphoma growth in mice in vivo.
