- 中文名称
Phospho-p53（Ser15）易位测定试剂盒（基于细胞）
- 英文名字
- Phospho-p53 (Ser15) Translocation Assay Kit (Cell-Based)
- 供应商
- Biovision
- 产品货号
- K966-50
- 产品报价
- ￥询价/50assays
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868.
- 产品新闻
- 背景资料
- 待更新
- 产品描述
- Tumor protein p53 (TP53, p53) is a widely conserved transcription factor and tumor suppressor commonly referred to as the “guardian of the genome”. Due to the presence of transcriptional activation, DNA binding, and oligomerization domains, p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in p53 gene are associated with numerous human cancers and about 50% of those mutations result in loss of function. Multiple genotoxic and non-genotoxic stimuli lead to stabilization and activation of p53 that are mediated by numerous post-translational modifications. The N-terminus of p53 is heavily phosphorylated, whereas the C-terminus may be phosphorylated, acetylated neddylated, ubiquitinated or sumoylated. In unstressed cells, the level of p53 protein is downregulated via binding to MDM2, COP1, PIRH2 or JNK that promote p53 degradation. Cellular stress and Nutlin-3, a potent inhibitor of Mdm2-p53 interaction, activate and increase level of p53 in the cell due to lack of negative regulation. Presence of three putative nuclear localization signals (NLSs) on its C-terminus, promotes translocation of some of the activated p53 into the nucleus thus activating genes that induce cell cycle arrest, senescence, or apoptosis. BioVision’s Phospho-p53 (Ser15) Translocation Assay Kit provides a simple and complete assay in a ready to use format to visualize the nuclear translocation of activated p53 in mammalian cells.
- 产品特点
- Detection of nuclear translocation of phosphorylated p53 in mammalian cells
Characterize/Screen/Study for effectors of p53 cellular levels
Detection of cellular stress or DNA damage caused by genotoxic and non-genotoxic stimuli
- 保存建议
- -20
- 其他
- BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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