- 中文名称
磷酸化p38 MAPK（Thr¹+Tyr¹²²）易位测定试剂盒（基于细胞）
- 英文名字
- Phospho-p38 MAPK (Thr¹⁸⁰+Tyr¹⁸²) Translocation Assay Kit (Cell-Based)
- 供应商
- Biovision
- 产品货号
- K965-100
- 产品报价
- ￥询价/100assays
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868.
- 产品新闻
- 背景资料
- 待更新
- 产品描述
- Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate numerous physiological and pathophysiological cell responses. p38 MAPKs belong to a class that plays an important role during inflammatory processes, and their expression is upregulated by inflammatory and stress stimuli (cytokines, ultraviolet irradiation, osmotic and heat shock). p38 MAPKs are also involved in autophagy, apoptosis, cell differentiation, and are implicated in the regulation of inflammatory mediators levels such as tumor necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2). Accumulating evidence suggests that p38 MAPKs play an important role in arthritis, and inflammation of the liver, kidney, brain, and lung. Diseases induced by chronic inflammation, including gastritis, colitis, dermatitis, rheumatoid arthritis, pulmonary diseases and type II diabetes affect millions of people every year. Therefore, p38 is an important target in better understanding of inflammation and development of novel treatments. p38 MAPK is activated following phosphorylation at Thr180/Tyr182 by upstream MKK6 and MKK3 kinases. While in quiescent cells p38 localizes to both nucleus and cytosol, stress induced conformational changes within the active site result in selective translocation of activated-p38 into the nucleus. Thus, the selective nuclear accumulation of p38 could be a mechanism to facilitate the phosphorylation of p38 MAPK nuclear targets. BioVision’s Phospho-p38 MAPK (Thr180+Tyr182) Translocation Assay Kit (Cell-Based) provides a valuable tool to detect the nuclear translocation of activated p38 in fixed mammalian cells.
- 产品特点
- Detection of nuclear translocation of phosphorylated-p38 in mammalian cells
Screening effectors of p38 MAPK signaling pathway
Detection of cellular stress, DNA damage, heat shock, and pro-inflammatory stimuli
- 保存建议
- -20
- 其他
- BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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