- 中文名称
p53核转运分析试剂盒（基于细胞）
- 英文名字
- p53 Nuclear Translocation Assay Kit (Cell-Based)
- 供应商
- Biovision
- 产品货号
- K961-50
- 产品报价
- ￥询价/50assays
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868.
- 产品新闻
- 背景资料
- 待更新
- 产品描述
- p53 is a tumor suppressor gene which encodes a transcription factor that controls cell’s destiny. This gene gets activated when cells are exposed to increased cellular stress, or DNA damage. The levels of p53 are elevated when post-translational modifications occur, which block its sequestration and/or ubiquitination by its destabilizer, Mouse Double Minute 2 Homolog (MDM2) which in turn is a transcriptional target of p53. Due to the three putative nuclear localization signals (NLSs) on its C-terminus, some of the activated p53 protein translocates into the nucleus and activate genes that induce cell cycle arrest, senescence, or apoptosis. The p53 gene is frequently mutated in cancer cells, and about 50% of cancers show p53 mutations, resulting in loss of its functions. The loss of p53 functionality can lead to dysregulation of many biological processes in cells, such as metabolic pathways, cellular homeostasis, cell movement, apoptosis, etc. BioVision’s p53 Nuclear Translocation Assay Kit (Cell-Based) provides an easy and complete assay kit to visualize the activation and nuclear translocation of p53 in human cells. This assay kit uses BioVision’s specific and sensitive human p53 antibody and a p53 secondary antibody to visualize the localization of p53 in fixed common human cells along with DAPI, a fluorescent stain, for nuclear staining. The kit includes Nutlin-3, a potent selective inhibitor that disrupts the protein-protein interaction between p53 and MDM2. Nutlin-3 serves as a control to induce p53 translocation from the cytoplasm to the nucleus
- 产品特点
- • Simple procedure to visualize p53 nuclear translocation in ~ 3 hours
• Fast and contains Nutlin-3 that serves as a control to induce p53 translocation from the cytoplasm to the nucleus.
- 保存建议
- -20
- 其他
- BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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