HSPB7 is part of the Heat shock protein beta family. The HSPB family is one of the more diverse families within the group of HSP families. Several members have chaperone-like activities and/or participate in cytoskeletal stabilization. Several members also show a dynamic, stress-induced translocation to SC35 splicing speckles. HSPB7 constitutively localized to SC35 splicing speckles, determined by its N-terminus. HSPB7 does not support refolding though HSPB1 and HSPB5 chaperone heat unfolded substrates and keet them folding competent.