Lysophosphatidylcholine acyltransferase 1（LPCAT1) is a part of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. LPCAT1 is a key enzyme for remodeling phospholipids， including phosphatidylcholine. LPCAT1 possesses both acyltransferase and acetyltransferase activities and also mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine（LPC) into phosphatidylcholine（PC). LPCAT1 presents a clear preference for saturated fatty acyl-CoAs， and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors， respectively. LPCAT1 synthesizes phosphatidylcholine in pulmonary surfactant and therefore playing an important role in respiratory physiology.
