Phosphoglycerate mutase 2（PGAM2) is a member of the phosphoglycerate mutase family. PGAM is a dimeric enzyme which contains in separate tissues， different proportions of a slow-migrating muscle（MM) isozyme， a fast-migrating brain（BB) isozyme， and a hybrid form（MB). PGAM（Phosphoglycerate mutase) catalyzes the reversible reaction of 3-phosphoglycerate（3-PGA) to 2-phosphoglycerate（2-PGA) in the glycolytic pathway. PGAM2 gene mutations cause muscle phosphoglycerate mutase efficiency， otherwise known as glycogen storage disease X.
