- 中文名称
Extractable Nuclear Antigen, Human, IgG, BioAssay ELISA Kit (ENA)
- 英文名字
- Extractable Nuclear Antigen, Human, IgG, BioAssay ELISA Kit (ENA)
- 供应商
- USBiological
- 产品货号
- E9011
- 产品报价
- ￥1/1Kit
- 产品说明书
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- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！
- 产品描述
- The United States Biological Extractable Nuclear Antigen, Human, IgG, BioAssay ELISA Kit is designed to detect IgG class antibodies to Jo-1, Sm, Sm/RNP, SSA(Ro), SSB(La), and Scl-70 in human serum. Wells of plastic microwell strips are sensitized by passive absorption with immobilized antigens. In recent years it has become clear that autoantibodies to a number of nuclear constituents have proven to be useful in the diagnosis of various connective tissue diseases. The Jo-1 autoantibody is one of a family of characteristic autoantibodies seen in myositis patients. They are all specifically found in patients with myositis, and are all associated with a high incidence of accompanying interstitial lung disease. Antibodies directed against the Sm marker are highly specific for patients with SLE and are considered a diagnostic criterion for SLE. The presence of high level RNP antibodies alone are considered diagnostic of mixed connective tissue disease (MCTD) and are usually associated with a more benign disease course, while patients with low levels of RNP antibodies, together with other autoantibodies, may be observed in the serum of patients with progressive systemic sclerosis, Sjögren's Syndrome, and rheumatoid arthritis. The presence of RNP antibodies in the serum of SLE patients is usually associated with a lower incidence of renal involvement and a more benign disease course. To the contrary, patients with Sm antibodies experience a higher frequency of renal and central nervous system complications. Autoantibodies directed against SSA and SSB may be observed in patients with SLE and Sjögren's disease. SSA antibodies are frequently present in the serum of ANA negative SLE patients, such as subacute cutaneous lupus erythematosus, a lupus-like syndrome associated with a homozygous C2 deficiency, and in a subset of patients who lack anti-dsDNA antibodies. Scl-70 antibodies are highly specific for scleroderma. They are also observed in a minority of SLE patients. Scl-70 positive scleroderma patients tend to have a more severe disease course, more internal organ involvement and diffuse rather than limited skin involvement. Scl-70 antibodies are rarely found in other autoimmune diseases, and thus, their detection in a patient with the recent onset of Raynaud's phenomenon is highly significant. The relative frequency of these autoantibodies in association with SLE and other connective tissue diseases either singly, or as multiple autoantibodies, requires an autoantibody profile assessment of each patient's serum in order to obtain the highest degree of clinical relevance in the laboratory workup of these types of patients. Until recently, autoantibodies were tested individually by indirect immunofluorescence, Ouchterlony gel diffusion, hemagglutination, radioimmunoassay, or ELISA. Although the exact etiology of autoimmune diseases is unknown, and the specific role played by autoantibodies in the onset of various autoimmune connective tissue diseases is obscure, the association and frequency of detection of these antibodies, particularly those of the IgG class, by the Extractable Nuclear Antigen, Human, IgG, BioAssay ELISA Kit, offers an efficient test procedure for the research of various connective tissue diseases. Kit Components: 1. Microtiter Plate: 1X96wells2. IgGy, Goat x human (HRP): 1X15ml3. Positive control: 1X350ul4. Calibrator: 1X500ul5. Negative Control: 1X350ul6. Sample Diluent: 1X30ml7. Tetramethylbenzidine (TMB): 1x15ml8. Stop Solution:1X15ml (1N H2SO4)9. Wash Buffer, 10X: 1X100ml Storage and Stability:Store all components at 4°C. Stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- 产品特点
- 针对Extractable Nuclear Antigen, Human, IgG, BioAssay ELISA Kit (ENA)该产品的特点优势，欢迎查阅官网提供的产品说明书。
- 保存建议
- 建议收到Extractable Nuclear Antigen, Human, IgG, BioAssay ELISA Kit (ENA)产品后将其置于4°C保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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