GMFG is a hematopoietic-specific protein that mediates the pluripotentiality and lineage commitment of human hematopoietic stem cells. Glia maturation factor gamma is a cytokine-responsive protein in EPO-induced and G-CSF-induced hematopoietic lineage development. Glia maturation factor also acts as a Nerve Growth Factor in nervous system development，angiogenesis and immune function. GMFG possesses hematopoietic tissue-specific gene expression，a promoter concentrated with high-score hematopoiesis-specific transcription factors，and molecular coevolution with a rudimentary blood/immune system.
