Insulin-like growth factor-binding protein 4 (IGFBP-4) belongs to the insulin-like growth factor binding protein (IGFBP) family. IGFBP4 includes an IGFBP domain and a thyroglobulin type-I domain. IGFBP4 binds both insulin-like growth factors (IGFs) I and II. IGFBP-4 circulates in the plasma in both glycosylated and non-glycosylated forms. IGFBPs can either inhibit or enhance the biological activities of IGF,or act in an IGF independent manner. IGFBP-4 is exceptional since it consistently inhibits several cancer cells in vivo and in vitro,suggesting that it may function as an apoptotic factor. IGFBP4 is produced by all colon cancer cells. Binding of IGFBP-4 prolongs the half-life of the IGFs and changes their interaction with cell surface receptors.
人胰岛素样生长因子结合蛋白-4产品在室温条件下可以保存3周,应该置于-18℃或更低温度下干燥保存.
Upon reconstitution IGFBP-4 should be stored at 4°C between 2-7 days and for future use below -18°C.
推荐添加载体蛋白 (0.1% HSA或BSA)以长期保存,请避免反复冻融.