CellMosaic® has designed this kit to label any Protein (MW ≥ 20KDa) with SN38, the active metabolite of irinotecan, for early stage screening of your antibody.
Irinotecan is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. SN38 is 1000-times more active than irinotecan, but is not generally used as a drug due to its poor water solubility. If it is conjugated to a protein or antibody, the protein/antibody can transport SN38 to the active site. This kit includes O-succinyl SN38 NHS ester, which can be coupled to the protein directly via surface amines in a single step. The product is then purified to remove any unreacted drug.
