Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels， thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts， PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的重组人人血小板因子4（CXCL4）， His Tag产品为溶液形式（0.25mg/ml的PF4蛋白溶解于20mM Tris-HCl缓冲液（pH 8.0）， 0.2M NaCl， 50%甘油和2mM DTT）形式.
