Macrophage Inflammatory Proteins （MIP） belong to the family of chemotactic cytokines known as chemokines. In humans， there are two major forms， MIP-1a and MIP-1b that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They activate human granulocytes （neutrophils， eosinophils and basophils） which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 （IL-1）， IL-6 and TNF-a from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的重组小鼠巨噬细胞炎症蛋白-1 alpha（CCL3）， His Tag产品为无菌的澄清溶液形式.
保存建议
整瓶保存于4℃时，应在2-4周用完.长期保存应置于-20℃.
长期保存，推荐添加载体蛋白 （0.1% HSA or BSA）.
请避免反复冻融.
