Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2.
应用类型
ICC/IF,WB,IHC-F,IHC-P,ELISA
免疫原
The antiserum was produced against synthesized peptide derived from human C-RAF. AA range:251-300
