Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo.
应用类型
WB,IHC-F,IHC-P,ICC/IF,ELISA
免疫原
The antiserum was produced against synthesized peptide derived from human Retinoblastoma. AA range:751-800
