- 中文名称
RAE1 polyclonal antibody
- 英文名字
- RAE1 polyclonal antibody
- 供应商
- Bioworld
- 产品货号
- BS8377
- 产品报价
- ￥询价/50ul
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Natural killer (NK) cells attack tumor and infected cells, but the receptors andnligands that stimulate them are poorly understood. Two murine ligands fornthe lectin-like receptor NKG2D, H60 and retinoic acid early inducible (Rae-n1α, β, γ, δ and ε), are distant relatives of major histocompatibility complexnclass I molecules. These molecules are encoded by Rae-1 and H60 minornhistocompatibility antigen genes on mouse chromosome 10 and show weaknhomology with MHC class I. Expression of the NKG2D ligands is low or absentnon normal, adult tissues; however, they are constitutively expressed on somentumors and upregulated by retinoic acid. Ectopic expression of Rae-1 andnH60 confers target susceptibility to NK cell attack. NKG2D binds to H60 withnapproximately 25-fold higher affinity than to Rae-1. Rae-1 and H60 competendirectly for occupancy of NKG2D; therefore, NKG2D can be occupied by only one ligand at a time. Additionally, Rae-1 and H60 ligands of the NKG2Dnreceptor stimulate tumor immunity.
- 应用类型
- WB
- 免疫原
- Recombinant full length Human RAE1.
- 来源宿主
- Rabbit
- 反应性
- Human, Mouse, Rat
- 保存建议
- Store at 4
- 其他
- Bioworld是专一服务于生命科学研究的专业技术型企业，Bioworld品牌创立以来拥有10000多种常规产品现货，现有8000多种现货抗体，以及其他IVD原料，蛋白等现货产品。在细胞信号通路、免疫学、蛋白组学上拥有显著优势，其抗体产品、生长因子、IVD原料等为生命科学科研工作者提供了极大的便利
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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