EPS15L1 (Epidermal Growth Factor Receptor Pathway Substrate 15-Like 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and EGFR1 Signaling Pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is ITSN1. Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
