Biotin-PEG11-Gly-Gly-Gly-amine is a chemical reagent with a biotin group, a hydrophilic PEG spacer, a glycine tripeptide, and a primary amine. Biotin has applications in a broad range of biochemical techniques, particularly in affinity-based assays such as pulldown assays. Meanwhile, the amine is free to perform a variety of reactions such as coupling with carboxylic acids, reductive amination with aldehydes or ketones, or nucleophilic substitution on electron-deficient aromatic rings.