BCN-PEG3-VC-PFP Ester is a cleavable ADC linker featuring a BCN group, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PFP ester. The PFP ester is activated towards nucleophilic attack from amines, while BCN is a click chemistry handle which readily forms stable triazoles with azide groups on a target molecule. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery.
