TCO-PEG8-acid is a very reactive click chemistry reagent. The terminal carboxylic acid (CO2H) can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable bond. TCO moiety is reactive with tetrazine-containing compounds to form a stable bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
