欢迎您访问武汉艾美捷科技有限公司官方网站!
站点地图 服务热线:400-6800-868
  • 产品
  • 文章

PRODUCT CENTER

细胞因子
产品中心

当前位置:首页 > 产品中心 > 细胞生物学产品 > 细胞因子

中文名称

重组FGFR-1α(IIIc)-Fc,人

英文名字
RecombinantFGFR-1α(IIIc)-Fc,Human
供应商
Bioworld
产品货号
BK0354
产品报价
¥询价/10ug
产品说明书
点击查看
购买方式
银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868
产品新闻
背景资料
Fibroblast Growth Factor Receptor-1 (FGFR-1) is a transmembrane tyrosine kinase receptor belonging to the FGFR family. FGFR family has 4 members, FGFR-1 to FGFR-4, and they all have similar structural characteristics with 3 extracellular immunoglobulin-like (Ig) domains. FGFRs bind to FGFs with the second and third Ig domains, and complex with heparin sulfate when binding. The binding to FGF induces the dimerziation of FGFR and the phosphorylations of the intracellular tyrosines. Furthermore, the phosphorylated FGFR activates downstream signaling pathways, including STAT/JAK, RAS/MAPK, and PI3 K/AKT. Particularly, the signaling of FGFR-1 is stronger than that of FGFR-2, and sustains longer than that of FGFR-4. FGFR-1 is involved in the breast cancer: the patients with the FGFR-1 amplification are more likely to develop distant metastases, and the amplification of FGFR-1 is significantly associated with a shorter overall survival. Recombinant human FGFR-1 alpha(IIIc)-Fc (rhFGFR-1 alpha(IIIc)-Fc) produced in Sf9 is a single glycosylated polypeptide chain containing 592 amino acids. A fully biologically active molecule, rhFGFR-1 alpha(IIIc)-Fc has a molecular mass of around 90 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
序列
RPSP TLPEQAQPWG APVEVESFLV HPGDLLQLRC RLRDDVQSIN WLRDGVQLAE SNRTRITGEE VEVQDSVPAD SGLYACVTSS PSGSDTTYFS VNVSDALPSS EDDDDDDDSS SEEKETDNTK PNPVAPYWTS PEKMEKKLHA VPAAKTVKFK CPSSGTPNPT LRWLKNGKEF KPDHRIGGYK VRYATWSIIM DSVVPSDKGN YTCIVENEYG SINHTYQLDV VERSPHRPIL QAGLPANKTV ALGSNVEFMC KVYSDPQPHI QWLKHIEVNG SKIGPDNLPY VQILKTAGVN TTDKEMEVLH LRNVSFEDAG EYTCLAGNSI GLSHHSAWLT VLEALEERPA VMTSPLYLEG SGSGSGSPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK
来源宿主
SF9 insect cells
溶解建议
Reconstituted in ddH2O at 100 μg/mL.
保存建议
Lyophilized recombinant human FGFR-1 alpha(IIIc)-Fc (rhFGFR-1 alpha(IIIc)-Fc) remains stable up to 6 months at -80
其他
Bioworld是专一服务于生命科学研究的专业技术型企业,Bioworld品牌创立以来拥有10000多种常规产品现货,现有8000多种现货抗体,以及其他IVD原料,蛋白等现货产品。在细胞信号通路、免疫学、蛋白组学上拥有显著优势,其抗体产品、生长因子、IVD原料等为生命科学科研工作者提供了极大的便利
注意
该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
在线留言
产品分类
特色产品 MORE
最近促销 MORE
  • 高品质保障 成熟的生产研发技术
  • 高性价比 价宜质优,性价比高
  • 高效省心 从购买到使用,放心无忧
  • 安全运输 完善的保护措施安全运输

微信扫码在线客服

微信咨询

全国免费技术支持

400-6800-868

在线客服