中文名称

重组MCP—2/CCL8，人

英文名字

RecombinantMCP-2/CCL8,Human

供应商

Bioworld

产品货号

BK0126

产品报价

￥询价/1mg

产品说明书

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购买方式

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产品新闻

背景资料

MCP-2 is a member of the chemokines, a group of 70-80 residue proteins sharing substantial sequence similarity. Within the chemokines, MCP-2 belongs to the CC subfamily, and is a member of the Monocyte Chemoattractant Proteins (MCPs), which includes MCP-1, MCP-2, MCP-3, MCP-4, and MCP-5. MCP-2 shares 60% homology with MCP-1, and both proteins can undergo reversible dimerization. The main receptors of MCP-2 are G-protein coupled receptors CCR1 and CCR5. MCP-2 is a potential target in HIV-1 infected human glial cells as it may play a role in the modulation of viral spread in the brain. Recently, researchers found that mouse MCP-2 is expressed in the skin as a novel agonist of CCR8 and plays a role in eosinophilic inflammation.Recombinant human MCP-2/CCL8(rhMCP-2) produced in E.coli is a single non-glycosylated polypeptide chain containing 76 amino acids. A fully biologically active molecule, rhMCP-2 has a molecular mass of 8.9kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.

序列

QPD SVSIPITCCF NVINRKIPIQ RLESYTRITN IQCPKEAVIF KTKRGKEVCA DPKERWVRDS MKHLDQIFQN LKP

来源宿主

Escherichia coli.

溶解建议

Reconstituted in ddH2O at 100 μg/mL.

保存建议

Lyophilized recombinant human MCP-2/CCL8(rhMCP-2) remains stable up to 6 months at -80

其他

Bioworld是专一服务于生命科学研究的专业技术型企业，Bioworld品牌创立以来拥有10000多种常规产品现货，现有8000多种现货抗体，以及其他IVD原料，蛋白等现货产品。在细胞信号通路、免疫学、蛋白组学上拥有显著优势，其抗体产品、生长因子、IVD原料等为生命科学科研工作者提供了极大的便利

注意

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