中文名称

重组I-TAC/CXCL 11，人

英文名字

RecombinantI-TAC/CXCL11,Human

供应商

Bioworld

产品货号

BK0114

产品报价

￥询价/10ug

产品说明书

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购买方式

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产品新闻

背景资料

I-TAC (Interferon-inducible T-cell α Chemoattractant), also known as CXCL11, is a chemokine belonging to the CXCL subfamily. Along with Interferon-γ induced Protein 10 kDa and Monokine Induced by Interferon-γ, I-TAC is strongly up-regulated by Interferon-γ and binds to the G-protein coupled receptor CXCR3. The expression of CXCR3 is associated with Th1-mediated immune responses and mediates chemotaxis of Th1 cells. I-TAC induces, maintains, and amplifies the inflammatory reactions, and sustains chronic immune responses against self-antigens. Although CXCR3 was thought to be the exclusive receptor of I-TAC initially, more evidence has shown that I-TAC can also bind to CXCR4 and CXCR7, and that I-TAC plays important roles in tumor development and angiostasis. Recombinant human I-TAC/CXCL11 (rhI-TAC) produced in E.coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rhI-TAC has a molecular mass of 8.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.

序列

MFPMFKRGR CLCIGPGVKA VKVADIEKAS IMYPSNNCDK IEVIITLKEN KGQRCLNPKS KQARLIIKKV ERKNF

来源宿主

Escherichia coli.

溶解建议

Reconstituted in ddH2O at 100 μg/mL.

保存建议

Lyophilized recombinant human I-TAC/CXCL11 (rhI-TAC) remains stable up to 6 months at -80

其他

Bioworld是专一服务于生命科学研究的专业技术型企业，Bioworld品牌创立以来拥有10000多种常规产品现货，现有8000多种现货抗体，以及其他IVD原料，蛋白等现货产品。在细胞信号通路、免疫学、蛋白组学上拥有显著优势，其抗体产品、生长因子、IVD原料等为生命科学科研工作者提供了极大的便利

注意

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