Fibroblast Growth Factor-10 (FGF-10) is a mitogen mainly produced by mesenchymal stem cells in the lung. FGF-10 belongs to the heparin binding FGF family, and is also known as Keratinocyte Growth Factor-2 (KGF-2). It shares homology with KGF and receptor binding to FGFR2-IIIb. However, while KGF induces proliferation and differentiation of various epithelial cells, FGF-10 promotes budding and branching morphogenesis during the multi-organ development via mesenchymal-epithelial cell interactions. FGF-10 is critical for lung and limb development, and is regulated by Shh during early development. Recombinant Human FGF-10 produced in E.coli is a single, non-glycosylated polypeptide chain containing 169 amino acids. A fully biologically active molecule, rhFGF-10 has a molecular mass of 19.3 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
序列
LGQDMVSPEA TNSSSSSFSS PSSAGRHVRS YNHLQGDVRW RKLFSFTKYF
LKIEKNGK
VS GTKKENCPYS ILEITSVEIG VVAVKAINSN YYLAMNKKGK
LYGSKEFNND CKLKERIE
EN GYNTYASFNW QHNGRQMYVA LNGKGAPRRG
QKTRRKNTSA HFLPMVVHS
来源宿主
Escherichia coli.
溶解建议
Reconstituted in ddH2O at 100 μg/ml.
保存建议
Lyophilized recombinant Human FGF-10 remains stable up to 6 months at -80
