NGFR / p75ECD快速ELISA试剂盒：小鼠（2个板）-NGFR/p75ECD Rapid ELISA Kit: Mouse (2 Plates)-ELISA试剂盒-艾美捷科技有限公司

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背景资料: The nerve growth factor (NGF) receptor (NGFR), also known as p75 neurotrophin receptor (p75NTR; TNFRS16; CD271) is a common receptor for the neurotrophins NGF, BDNF, NT-3 and NT-4/5. In neurons, p75NTR mediates a variety of physiological functions including survival, apoptosis, neurite outgrowth and synaptic plasticity. A potential pathological role for p75NTR has become evident in recent years. Altered p75NTR expression levels are implicated in degeneration of spinal motor neurons in human and mouse models of amyotrophic lateral sclerosis (ALS). Importantly, the extracellular domain of p75NTR (p75ECD) is shed from the cell membrane and excreted in urine. Recent findings further suggest that p75ECD could be an early biomarker for ALS in humans, as significantly elevated p75ECD levels are found in urine of ALS patients as compared to healthy controls.

产品描述: The Biosensis NGFR/p75 ECD RapidTM enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the quantification of mouse p75 ECD in less than 4 hours n cell culture supernatants and urine only if used as directed. Please refer to the kit protocol for specific use instructions for each substrate application.
This ELISA kit consists of a pre-coated mouse monoclonal anti-p75 ECD capture antibody, a goat anti- p75 ECD detection antibody and a horseradish peroxidase (HRP)-conjugated anti-goat antibody. The addition of a substrate (3,3,5,5-tetramethylbenzidine, TMB) yields a colored reaction product which is directly proportional to the concentration of p75ECD present in samples and protein standards.
This NGFR/p75 ECD ELISA kit employs a recombinant mouse p75 ECD-Fc chimera protein as standard. While there is a current lack of a true mouse p75 ECD standard, this ELISA kit allows quantification of mouse p75 ECD as p75 ECD“Fc mouse equivalents. Please note that the antibodies used in this ELISA cross-react with human NGFR/p75 ECD.
This kit has not been tested for other applications. It has been configured for research use only and is not to be used in diagnostic or clinical procedures.

产品特点: 该ELIAS试剂盒包含：2 x 96孔预包被条孔板（可拆卸）, protein standards, detection reagents, wash and sample buffers, substrate buffer and detailed protocols.

其他: Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。Biosensis的产品系列不仅包括持续增长的神经科学研究抗体系列，还包括200多种定量研究ELISAs试剂盒（1板或2板，自由选择），组织染色（退化神经元染色试剂盒、病理髓鞘染色试剂盒、淀粉样斑块染色试剂等）和细胞可视化试剂（染色）以及针对神经科学和细胞疾病研究的纯化的蛋白质。我们的抗体和试剂已被广泛应用于各种技术，包括蛋白质印迹，免疫组织化学，流式分析，共聚焦显微镜实时成像，生物抑制和细胞培养以及克隆。