PF-04418948产品是PF-04418948 is a potent EP2 receptor antagonist with an IC₅₀ of 16 nM for human EP2 receptors. It also displays greater selectivity for EP2 receptors over EP1, 3, 4, DPI and CRTH2 receptors. It inhibits PGE2 induced increase in intracellular cAMP. In vivo activity includes reversing the PGE2 invoked relaxation of mouse trachea.