The LRIG1 protein Q96JA1 is coded by a gene on chromosome band 3p14.3, a region known to be deleted in various human cancers. This is considered to be a tumour suppressor gene in humans. LRIG1 is an integral cell-surface membrane protein, expressed by specific cells in various human tissues. Its 143-kDa form might be cleaved into 111-kDa and 32-kDa fragments. The LRIG1 protein may inhibit the growth of glial cell tumours and the down-regulation of the LRIG1 gene may be involved in the development and progression of the tumors.
