Caspase-3 is involved in the activation cascade of caspases, this cascade is responsible for apoptosis execution. It cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase-3 belongs to the group of effector caspases that are involved in the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others.
应用类型
Western blot (WB)
免疫原
Recombinant human Caspase-3 protein. UniProt: P42574
