CD44 is a cell-surface glycoprotein that plays a role in cell-cell interactions， cell adhesion and migration. CD44 is a receptor for hyaluronic acid and also interacts with other ligands， such as osteopontin， collagens， and matrix metalloproteinases. CD44 participates in a wide variety of cellular functions such as lymphocyte activation， recirculation and homing， hematopoiesis， and tumor metastasis. nCD44 and CD49d are putative activity markers and CD44 a potential novel therapeutic target in multiple sclerosis. Increased CD44 antigen is associated with relapses in non-small cell lung cancers.
应用类型
ELISA，WB
免疫原
Anti-human CD44 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CD44 amino acids 21-145 purified from E. coli.
