Chitinases catalyze the hydrolysis of chitin， which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes 8 human family members. CHI3L1 is a glycoprotein member of the glycosyl hydrolase 18 family. CHI3L1 lacks chitinase activity and is secreted by activated macrophages， chondrocytes， neutrophils and synovial cells. CHI3L1 is thought to play a role in the process of inflammation and tissue remodeling.
应用类型
ELISA， Western blot
免疫原
Anti-human CHI3L1 mAb， is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CHI3L1 amino acids 22-383 purified from E. coli.
