NANOG is a multidomain homeobox transcription factor which functions to maintain the undifferentiated state of pluripotent stem cells. NANOG expression counteracts the differentiation-promoting signals induced by the extrinsic factors LIF， Stat3 and BMP. Once NANOG expression is downregulated， cell differentiation can proceed. Proteins which regulate NANOG expression include transcription factors Oct4， SOX2， FoxD3， and Tcf3 and tumor suppressor p53.
应用类型
ELISA， Western blot and immunohistochemistry
免疫原
Anti-human NANOG mAb， is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NANOG amino acids 1-154 purified from E. coli.
