HIV-1， the causative agent of acquired immunodeficiency syndrome （AIDS）， contains an RNA genome which produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element （TAR） located downstream of the transcription initiation site. TARDBP is a transcriptional repressor which binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition， TARDBP regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
应用类型
ELISA， Western blot and immunohistochemistry
免疫原
Anti-human TARDBP mAb， is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TARDBP amino acids 1-260 purified from E. coli.
