GPS2 is a protein involved in G protein-mitogen-activated protein kinase （MAPK） signaling cascades. When overexpressed in mammalian cells， GPS2 could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity， suggesting that the function of the GPS2 may be signal repression. GPS2 is an integral subunit of the NCOR1-HDAC3 （nuclear receptor corepressor 1-histone deacetylase 3） complex， and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 （activator protein 1） function.
应用类型
ELISA， Western blot
免疫原
Anti-human GPS2 mAb， is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GPS2 amino acids 161-311 purified from E. coli.
