TLR2 belongs to the Toll-like receptor （TLR） family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns （PAMPs） which are expressed on infectious agents， and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes， and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
应用类型
ELISA， Western blot
免疫原
Anti-human TLR2 mAb， is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TLR2 amino acids 221-384 purified from E. coli.
