Human Phosphoserine phosphatase （hPSP） is an important enzyme in the phosphorylated pathway of serine biosynthesis， which contributes a major portion of the endogenous L-serine. Similar to known L-3-phosphoserine phosphatases， it catalyzed the Mg2+-dependent hydrolysis of L-phosphoserine and an exchange reaction between L-serine and L-phosphoserine. Recently， its complex structures reveal that the open-closed environmental change of the active site， generated -helical bundle domain， is important to substrate by local rearrangement of the recognition and hydrolysis.
应用类型
ELISA， Western blot
免疫原
Anti-human PSPH mAb， is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PSPH amino acids 1-225 purified from E. coli.
