高迁移率族蛋白B1(high mobility group protein,HMGB1)是一种高度保守的核蛋白,广泛分布于哺乳动物细胞.随着其晚期促炎作用的发现,HMGB1成为近年来危重医学研究的热点之一.本文就其家族分类、基因和蛋白结构、细胞生物学效应方究进展进行综述.
应用类型
ELISA, Western blot and immunohistochemistry
免疫原
Anti-human HMGB1 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HMGB1 amino acids 1-215 purified from High Five (Trichoplusia ni) insect cells.