FADD is an adaptor protein that cooperates with a variety of cell surface receptors and mediates cell apoptotic signals. Using its C-terminal death domain， FADD is recruited by TNFRSF6/Fas-receptor， tumor necrosis factor receptor， TNFRSF25， and TNFSF10/TRAIL-receptor， and consequently it take parts in the death signaling initiated by these receptors. FADD interaction with the receptors reviels the N-terminal effector domain of， which allows it to recruit caspase-8， and thus initiate the cysteine protease cascade. Knockout studies in mice furthermore propose the significance of FADD in premature T cell development. FADD plays a role in survival/proliferation and cell cycle development. FADD also takes part in cellular sublocalization， protein phosphorylation， and inhibitory molecules.
应用类型
ELISA， Western blot and immunohistochemistry
免疫原
Anti-human FADD mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human FADD amino acids 1-208 purified from E. coli.
