Integrin beta 1， also known as CD29， is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits （including alpha 1， alpha 2， alpha 3， alpha 4， alpha 5， and alpha 6， also known as CD49a， CD49b， CD49c， CD49d， CD49e， and CD49f， respectively） to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions， including embryonic development， wound repair， hemostasis， and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis， tumor cell growth， and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix l
应用类型
ELISA，WB
免疫原
Anti-human CD29 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CD29 amino acids 34-141 purified from E. coli.
