HtrA2 also called Omi is a mammalian serine protease at high temperatures and has a chaperone activity at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain； an inhibitor of apoptosis protein （IAP）-binding motif； a single C-terminal PDZ domain that mediates protein-protein interactions. Recently， HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death.
应用类型
ELISA， Western blot
免疫原
Anti-human HTRA2 mAb is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HTRA2 amino acids 134-458 purified from E. coli.
