TPD52L1 （hD53， hD53L1） is a member of D52 gene family and overexpressed in human breast carcinoma. TPD52L1 contains coiled-coil motif， which is responsible for homo- and heteromeric interaction， and may be a regulator of cell proliferation and calcium-mediated signal transduction. Moreover， TPD52L1 interacts with the mitogen-activated protein kinase kinase kinase 5 （MAP3K5/ASK1） and positively regulates MAP3K5-induced apoptosis.
应用类型
ELISA， Western blot and immunohistochemistry
免疫原
Anti-human TPD52L1 mAb， is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TPD52L1 amino acids 1-131 purified from E. coli.
