CD28 co-stimulation is necessary for CD4 positive T-cell proliferation & survival， interleukin-2 production， and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence.
应用类型
Blocking and staining antibody. For staining， use 10μl/1，000，000 cells. Titer for blocking T cell activation should be determined by the investigator.
