SARS Coronavirus is an enveloped virus containing three outer structural proteins, namely the membrane (M), envelope (E), and spike (S) proteins. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. Accordingly, S-protein plays an important role in virus infection cycle and is the primary target of neutralizing antibodies.
应用类型
western blot
免疫原
The antibody was developed using a synthetic peptide from the putative SARS Spike glycoprotein (Genbank accession no.NP_828851) corresponding to amino acids 19-35.