Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain （ITGB2） to form a leukocyte-specific integrin referred to as macrophage receptor 1 （’Mac-1’）， or inactivated-C3b （iC3b） receptor 3 （’CR3’）. The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium， and also in the phagocytosis of complement coated particles. Integrin alpha-m/beta-2 is implicated in various adhesive interactions of monocytes， macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD-11b is identical with cr-3， the receptor for the ic3b fragment of the third complement component. CD-11b probably recognizes the r-g-d peptide in c3b. Integrin alpha-m/beta-2 is also a receptor for fibrinogen， factor x and icam1. it recognizes p1 and p2 peptides of fibrinogen gamma chain.
应用类型
Staining and blocking antibody. For staining， use 10μl/1，000，000 cells. This antibody will block signaling through the CD11a molecule. Titer for blocking should be determined by the investigator.
