ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain （ITGB2） to form the integrin lymphocyte function-associated antigen-1 （LFA-1）， which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands， ICAMs 1-3 （intercellular adhesion molecules 1 through 3）， and also functions in lymphocyte costimulatory signaling.
应用类型
Staining and blocking antibody. For staining， use 10μl/1，000，000 cells. This antibody will block signaling through the CD11a molecule. Titer for blocking should be determined by the investigator.
