This gene is a member of a family of neurotrophic factors， neurotrophins that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor， brain-derived neurotrophic factor， and neurotrophin 3 prove lethal during early postnatal development， NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.
