NDE1 is a cytoplasmic protein which is a member of the nudE protein family. Phosphorylated during mitosis， NDE1 is critical for the formation and function of the mitotic spindle in M phase and functions to regulate the Dynein-mediated transport of kinetochore proteins， as well as centrosome duplication during interphase. NDE1 is believed to interact with NDEL1， LIS1 and Dynein IC1/2， cytosolic in a signaling pathway which regulates the formation of neurons and is fundamental to the development of the cerebral cortex.
应用类型
ELISA， Western blot
免疫原
Anti-human NDE1 mAb， is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NDE1 amino acids 1-335 purified from E. coli
