Pyridoxine-5’-phosphate oxidase （PNPO） is the rate-limiting enzyme in vitamin B6 synthesis. Vitamin B6 （Pyridoxal 5-prime-phosphate or PLP） is vital for normal cellular function， and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts.Vitamin B6 is an essential co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in the PNPO gene result in PNPO deficiency， a form of neonatal epileptic encephalopathy.
应用类型
ELISA， Western blot
免疫原
Anti-human PNPO mAb， is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PNPO amino acids 57-261 purified from E. coli.
