NANS is a 359 amino acid protein that contains one AFP （antifreeze proteins）-like domain and functions in the biosynthesis of sialic acids. The ubiquitously expressed NANS enzymatically catalyzes the H2O-dependent formation of N-acetylneuraminic acid （Neu5Ac） and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid （KDN）， both of which are sialic acids. NANS uses N-acetylmannosamine 6-phosphate as a substrate for Neu5Ac synthesis and mannose 6-phosphate as a substrate for KDN synthesis.
应用类型
ELISA， Western blot
免疫原
Anti-human NANS mAb， is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NANS amino acids 1-359 purified from E. coli.
