BAK1 is a member of the BCL2 protein family. The BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators which are involved in a wide variety of cellular activities. The BAK1 gene encodes a receptor-like kinase （RLK） with a putative extracellular domain， a single transmembrane domain， an intracellular-juxtamembrane domain， and a kinase domain. BAK1 localizes to mitochondria， and functions to induce apoptosis. BAK1 interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel， leading to a loss in membrane potential and the release of cytochrome c. Furthermore， BAK1 interacts with the tumor suppressor P53 after exposure to cell stress. BAK1 expression is linked to the progression of Prostate cancer.
应用类型
ELISA， Western blot and Immunofluorescence
免疫原
Anti-human BAK1 mAb， is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human BAK1 amino acids 29-187 purified from E. coli.
